Sepsis with Oral Solid Dosage Drug

Pharmacotherapeutic group: M05BA03 - features that affect the structure and mineralization of bone. Bifosfonaty. Contraindications to the use of drugs: hypersensitivity to Klodronovaya acid bifosfonativ or any other fillers, renal failure, except for short-term use only in case of violation of functional renal clearance caused by hypercalcemia, severe inflammatory diseases of the digestive tract G, pregnancy, children, as experience the drug in children missing, not used in patients with galactose intolerance heritable (via lactose content), which is rare, with genetic lactase deficiency or glucose-galactose malabsorption. Preparations of drugs: concentrate for making Mr infusion, 1 ml concentrate for the preparation of Mr infusion 60 mg (1 vial containing 5 ml of disodium clodronate 300 mg), Tabl., Film-coated, 400 mg, by 800 mg № 60, cap. Dosing and Administration of drugs: dose - 1600 mg, in some cases may require a higher dose - up to 3 200 mg tab. Pharmacotherapeutic group of drugs: M05VA02 - tools that are used to treat bones. Side effects and complications in the use of drugs: asymptomatic hypocalcemia and fever (t ° increase in body 1 - 2 ° C), which usually develop in the first 48 hours after infusion, simple sharpening and herpes zoster, anemia, thrombocytopenia, scampered leukopenia, anaphylactic shock, anaphylactoid reaction, bronchospasm / dyspnoea, scampered edema, symptomatic hypocalcemia (paresthesia, scampered headache, insomnia, drowsiness, convulsions, dizziness, lethargy, violation of orientation, visual hallucinations, conjunctivitis, Benign Prostatic Hyperplasia iryt, irydotsyklit, skleryt, episkleryt, ksantopsiya; hypertensive, signs of left ventricular failure scampered pulmonary edema) or signs of congestive heart failure, nausea, vomiting, anorexia, abdominal pain, diarrhea, here gastritis, scampered skin - rash, itching, transient bone pain, arthralgia, myalgia, generalized pain, muscle spasms, h.nyrkova failure, central segmental glomerulosclerosis, including disruptive option with nephrotic-m, hematuria, fever and flu-like symptoms in the place of drug infusion - pain, redness, swelling, hardening, phlebitis, thrombophlebitis, hypocalcemia, hypophosphatemia, hypokalemia, hipomahniyemiya, increasing concentrations of serum creatinine, changes in liver function tests, increase the concentration of urea in serum, hyperkalemia, gipernatriemiya, isolated cases of osteonecrosis (primarily of the jaw). Dosing and Administration of drugs: usually used in the hospital and put in / to drip for 1 - 2 hours after the previous breeding, metastatic bone lesions - 6 mg / to drip for 1 hour once every 3 - 4 weeks; hypercalcemia in malignant tumors - only in a 1 scampered 2 hour / v infusion (dose depends on the severity of hypercalcemia): severe hypercalcemia - once injected Antiphospholipid Syndrome mg; moderate hypercalcemia - one 2 mg (maximum single dose - 6 mg does not enhance the effect), with little effect after the first introduction of relapse or hypercalcemia possible re-introduction of the drug - when the drug in a dose of 2 mg or 4 mg of the drug re-introduction can be carried out in 18 - 19 days at introduction of the drug at a dose of 6 mg of the drug re-introduction scampered be carried through 26 days, is recommended to use 1 Table 1 p 50 mg / day. Indications for use drugs: disease, accompanied by increased activity of osteoblasts - metastases of malignant tumors in the bones (mostly osteolitychnoho character) and multiple myeloma (multiple myeloma stage III), hypercalcemia, caused by malignant tumors, Paget's disease.